Dosage
For roundworms, hookworms and tapeworms.
50 mg /kg body weight - 1 - 100 mg tablet per 2 kg bodyweight or 1 - 500 mg tablet per 10 kg bodyweight.

Example:

Routine Treatment Schedule
Pups: Can be dewormed at the age of 2, 4, 6, 8 and 12 weeks in view of the danger of re-infection by ascarids.
Adult Dogs: Deworming once or twice a year as prescribed by the veterinarian.
Breeding Bitches: Treat after mating and shortly before and 4 weeks after whelping.
Kennels: Because of the increased infection risk, it is recommended that all dogs in breeding kennels be dewormed 4 to 6 times a year.

Toxicology
Acute LD50 values
Mouse: 3177 mg / kg
Rat: 3503 mg / kg
Rabbit: 10,000 mg / kg

Signs of acute toxicity are sedation, dyspnea, exophthalmos, curved position and ruffled fur. No organ changes were seen.

Twenty cross-bred dogs, eleven males / nine females, were treated up to 2000 mg/kg. Some of the dogs given 500 mg /kg or more vomited after treatment, and all dogs showed some general depression and inappetence for 48 hours after the treatment. No dogs died as a result of the treatments. In clinical chemistry tests carried out, no correlation was found between deviation from control values and treatment rate.

Chronic Study
Six beagle cross-bred puppies, four male and two female, were used in this study. An initial dose of 200 mg / kg at the age of three weeks, and 26 subsequent two weekly doses at the rate of 100 mg / kg were administered. No symptoms of toxicity were observed in the treated dogs (4/6). Seven quantitative parameters were examined, and no significant changes were observed which could be related to the chemical treatment. When the dogs had reached maturity, sperm mobility tests gave no indication of abnormalities. The bitches were joined by treated dogs and have produced normal progeny.

Reproduction Studies
LOPATOL did not have any toxic effect on pregnant bitches or their litters apart from a slight increase in some individual enzyme levels.

No clinical symptoms of toxicity or abortion were observed and all bitches receiving LOPATOL delivered healthy puppies at the end of their normal gestation period.

Contraindications
As with other vermicides, LOPATOL should not be administered to severely debilitated animals.

Warnings
Keep out of reach of children.

Adverse Reactions
Vomiting that may occur has no negative influence on the efficacy of LOPATOL Tablets.

Precautions
LOPATOL should not be administered concomitantly with other anthelmintics.

Packaging
LOPATOL 100 Boxes of 6 tablets which are packaged 24 in a display carton
LOPATOL 500 Boxes of 4 tablets which are packaged 24 in a display carton