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Companion Animal Business


The following is a portion of the Clomicalm Product Monograph. Please visit your veterinarian if you have any questions concerning this product.

CLOMICALM® is a twice daily oral treatment for dogs which has been shown to be effective when administered in combination with behavioural modification techniques for the treatment of anxieties and stereotypies (obsessive compulsive disorder).


Novartis Animal Health Canada Inc. encourages you to take time to read this package insert which describes the use of CLOMICALM® (Clomipramine hydrochloride) to treat certain behavioural concerns in dogs. CLOMICALM® is only available through veterinarians.


The active ingredient in CLOMICALM® is clomipramine hydrochloride. The active ingredient in vivo is clomipramine and its major metabolite, desmethylclomipramine. Both clomipramine and desmethyclomipramine contribute to the broad-sprectrum of action of CLOMICALM® by blocking the neuronal re-uptake of both noradrenaline and serotonin (5-HT). CLOMICALM® therefore possesses the properties of both a tricyclic antidepressant and a serotonin re-uptake inhibitor.


Treatment of anxieties. Treatment of stereotypies (obsessive compulsive disorders) such as lick dermatitis.

Facts About Separation Anxiety in Dogs

Separation anxiety is defined as a dog’s distress response to physical separation from the people it is attached to, typically its owners. Whenever the people they are attached to leave, the symptoms of separation anxiety are demonstrated. When they return home the dog may demonstrate excessive greeting behaviour.

Up to 14% of dogs exhibit one or more of the signs of separation anxiety when left alone or separated from the people to whom they are most attached (From Pet Owner survey, Feb 1997. All Points Research).

Clinical signs of separation anxiety that are demonstrated when the dog is left alone include:

  • Barking or whining
  • Inappropriate urination and/or defecation
  • Destructive behaviour (scratching doors, shredding rugs)

Other signs include:

  • Agitation
  • Excessive salivation
  • Pacing
  • Anorexia (during times of separation)
  • Closely following attachment person(s)
  • Excessive licking or grooming
  • Trembling
  • Excessive greeting

Many dogs with separation anxiety are model pets when in the company of their owners, but their behaviour changes when alone.

Treatment of separation anxiety includes medication and behaviour training (simple guidelines for interacting with the dog.)

An expert in animal behaviour should be consulted in cases of dogs that exhibit signs of aggression (growling, snapping or biting people or other dogs) in addition to the signs of separation anxiety.

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